Which painkiller works for toothache? Paracetamol, ibuprofen and what to watch out for

The painkillers most often used for toothache, and shown to work in studies, are anti-inflammatories such as ibuprofen and naproxen, and paracetamol. Paracetamol is usually the safer choice for people with stomach or kidney problems, those on blood thinners and pregnant women. But painkillers only buy time: the decay, inflammation or abscess causing the pain won't go away without treatment. This article explains which medicine suits whom and when waiting becomes risky.

Which painkiller works for toothache? Paracetamol, ibuprofen and what to watch out for

Which painkiller is used for toothache?

Active ingredientHow it worksCaution
IbuprofenReduces pain and inflammation togetherMay be unsuitable with stomach or kidney disease, blood thinners and in pregnancy
NaproxenSimilar to ibuprofen, longer-lastingSame cautions as ibuprofen
ParacetamolReduces pain and fever, not inflammationTake care with liver disease and regular alcohol use; don't exceed the daily maximum
AspirinA painkiller, but increases bleedingAvoid before an extraction and in children; never place it on the tooth or gum

Most toothache comes from inflammation inside or around the tooth, so anti-inflammatories (ibuprofen, naproxen) give many people clearer relief than paracetamol. Studies have shown that ibuprofen and paracetamol taken together work well for dental pain; check with your pharmacist or doctor before combining them.

Who needs to be careful with which medicine?

  • People with stomach ulcers, gastritis or a history of stomach bleeding: ibuprofen and naproxen can irritate the stomach; paracetamol is usually more suitable.
  • People on blood thinners: anti-inflammatories and aspirin increase the risk of bleeding. We cover dental care for heart patients in dental treatment for heart patients.
  • People with kidney disease, heart failure or high blood pressure: don't take anti-inflammatories without medical advice.
  • Pregnant women: painkillers in pregnancy should be chosen with your doctor; anti-inflammatories are generally avoided, especially in the second half of pregnancy. See dental treatment in pregnancy.
  • Breastfeeding mothers: most painkillers are compatible with breastfeeding, but check dose and duration in dental treatment while breastfeeding and with your doctor.
  • Children: aspirin is not given to children; doses are based on weight, so always ask a paediatrician or pharmacist.

Many cold and flu remedies also contain paracetamol. Taking them with a painkiller can push you over the daily maximum without realising.

Common mistakes: aspirin on the tooth, antibiotics for pain

  • Putting aspirin on the tooth: it doesn't relieve the pain and causes a chemical burn and sore on the gum.
  • Trying to stop the pain with antibiotics: antibiotics are not painkillers and don't treat inflammation inside the tooth on their own. We explain when they are needed in antibiotics for toothache.
  • Raising the dose or switching medicines often: if the pain doesn't go, the answer is treating the cause, not more medicine.
  • Putting off treatment because the pain stopped: severe pain that suddenly stops can mean the nerve is dying; infection can progress quietly. See what is a dead tooth?

What you can do at home alongside medicine

  • Hold a cold compress on the outside of your cheek for 10–15 minutes; heat can make swelling worse.
  • Don't chew on the painful side; avoid very hot, very cold and sugary food.
  • Raise your head slightly when lying down; it can help pain that gets worse at night.
  • To tell whether the pain is coming from the tooth, sinus or ear, see can toothache cause ear pain? and can sinusitis cause toothache?

We've gathered the general steps in how to relieve toothache.

When is it dangerous to keep waiting with painkillers?

In these situations don't try to manage with painkillers; see a dentist the same day:

  • swelling of the face, under the jaw or around the eye;
  • fever, feeling unwell, difficulty swallowing or opening your mouth;
  • pain lasting more than 2–3 days despite painkillers, or pain that wakes you up;
  • a pimple-like bump on the gum or a bad taste in the mouth.

Swelling spreading quickly across the face and neck, or difficulty breathing, needs emergency care. We explain swelling in dental abscess.

Toothache examination in Beylikdüzü

At Dent32 we find the source of the pain with an examination and X-ray and, where needed, carry out first treatment the same day to relieve it; we share the options for a lasting solution in writing. For evening and weekend options, see emergency toothache.

Dent32 is at Barış Mah., Ginza Lavinya, E-5 Yanyolu No:30 D:179, 34520 Beylikdüzü, Istanbul and is open seven days a week. To book, call or WhatsApp +90 555 011 33 68, or use our contact page. At the examination we share the findings, the options and the approximate cost in writing; you are under no obligation to start treatment afterwards.

Frequently asked questions

What is the most effective painkiller for toothache?

Because toothache is usually linked to inflammation, anti-inflammatories such as ibuprofen work better for many people. Paracetamol is usually more suitable for people with stomach or kidney problems, those on blood thinners and pregnant women. Choose with your pharmacist or doctor.

Can paracetamol and ibuprofen be taken together?

Studies have shown that taking the two together works well for dental pain. Dose and suitability vary from person to person, so ask your pharmacist or doctor before combining them.

Does aspirin on the tooth stop the pain?

No. Placed on the tooth or gum, aspirin doesn't relieve pain and causes a chemical burn and sore in the tissue.

Do antibiotics cure toothache?

Antibiotics are not painkillers. A dentist may prescribe them in specific situations such as spreading infection and swelling; inflammation inside the tooth is treated with dental treatment such as a root canal or extraction.

How many days can I take painkillers?

Painkillers are for the short time until treatment. If you need them for more than 2–3 days, the cause needs treating; long-term use raises the risk of side effects and hides the problem.

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